Long-term opioid use changes the way nerve cells work in your brain1

  • When opioids are initially taken, your body produces lower levels of a naturally occurring hormone, called norepinephrine, that can affect breathing, muscle tension, and the ability to sleep
  • This can happen to any person who takes opioids for more than a few days, whether or not the opioid has been prescribed by their doctor2
  • Over time, your nerve cells become used to having opioids around. Because opioids have lowered your levels of norepinephrine, your body responds by adjusting these levels

When opioids are taken away suddenly, there is an imbalance of norepinephrine1

  • You begin to feel lots of very unpleasant feelings and reactions. These are known as withdrawal symptoms

LUCEMYRA helps adjust the balance of norepinephrine in the areas of your brain that cause withdrawal symptoms1,3

  • This helps restore the chemical balance and helps relieve the symptoms that occur during opioid withdrawal

Watch how LUCEMYRA helps relieve symptoms of opioid withdrawal

LUCEMYRA is not a treatment for Opioid Use Disorder (OUD), which is also called opioid addiction. If you have been diagnosed with OUD, your doctor may prescribe LUCEMYRA as part of a complete treatment program for your OUD. This program continues after LUCEMYRA treatment is completed and may also include maintenance medications combined with behavioral counseling.


  1. Kosten TR, George TP. The neurobiology of opioid dependence: implications for treatment. Sci Pract Perspect. 2002;13-20.
  2. Polston GR, Wallace MS. Analgesic agents in rheumatic disease. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR, eds. Kelley and Firestein’s Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier. 2017.
  3. LUCEMYRA™ (lofexidine) [Prescribing Information]. Louisville, KY: US WorldMeds, LLC; 2018.